Why is there such caution regarding Russia’s rush to release a vaccine into the market? I read about the example of the Dengue fever vaccine released in 2016 by Sanofi Pasteur – the only one whose vaccine, Dengvaxia, was recognized as effective at an early stage by regulatory bodies in 18 countries and approved for mass use. It was created by replacing two genes in the DNA of a weakened strain of the yellow fever virus with the corresponding genes of the dengue fever virus.
Thus, human trials over six years showed that it should only be administered to those who have already once had this viral disease. In people who have never had dengue, vaccination increases the risk of severe forms of the disease, and in children under 5 years old, the likelihood of severe forms increases seven-fold (with a mortality rate of about 50%) compared with those who did not receive the vaccine (https://www.sciencemag.org/news/2017/11/if-you-haven-t-had-dengue-infection-don-t-use-our-vaccine-drug-company-warns). However, the vaccine is still effective: people who have had dengue usually only develop long-term immunity against a specific type of the five existing types, but the vaccine provides protection against all variants of the dengue virus.
Another story from the fifties. Just by the way. Chemie Grünenthal released Thalidomide – a sedative. To help with sleep. And it was prescribed as an anti-emetic for morning sickness. In 1960 alone, 14.6 thousand tons of the drug were sold.
Thalidomide was described as a non-barbiturate sedative that could put the patient into a deep sleep without hangover and the risk of addiction development. This was a clear marketing advantage of the medicine over the first generation of sleeping pills. They disrupted the sleep structure and with repeated use led to an addiction development comparable to narcotics.
During testing on rodents, the median lethal dose of the drug could not be determined, so thalidomide was considered quite safe for humans. The creators of the drug did not test for harmful teratogenic effects — disruption of embryonic development. In simple terms, thalidomide was not tested on pregnant animals. There were reasons for this, but more on that below.
By various estimates, thalidomide caused severe anomalies in 8000—12000 children. About 40% of infants did not survive their first birthday. There were reports of an increased number of miscarriages during this period.”
Here are the details – https://tech.onliner.by/2019/05/11/talidomid
So, the protocols in pharmacology are “written in blood,” and ignoring them can theoretically lead to breakthroughs in science, but at the cost of human lives. During the war, Japanese and German medics discovered a lot (Google Unit 731 https://ru.m.wikipedia.org/wiki/Отряд_731 and Siegfried Ruff, although it’s well compiled here: https://knife.media/mengele-731/)
Hi, I'm Rauf Aliev. 