Metchnikoff: Beyond Science and Survival | November 13 2025, 04:53

I was reading Metchnikoff’s biography (don’t ask why I ended up there) and thought about how much can fit into one life. He wasn’t just a scientist, but rather like a saga:

His elder brother Ivan was the prototype for Leo Tolstoy’s “The Death of Ivan Ilyich.” Another brother, Lev, was a prominent anarchist, sociologist and fought in Italy alongside Garibaldi. Metchnikoff himself tried to end his life twice: the first time after the death of his first wife (who, sick with tuberculosis, was carried to the church on a chair). He took morphine but survived. The second time was when his second wife Olga fell critically ill with typhus. He deliberately inoculated himself with relapsing fever. Fortunately, both survived. However, the Grim Reaper with his scythe only came after his third consecutive heart attack.

The dude graduated from university at 19 as an external student. I.M. Sechenov himself recommended him for a professorship. But Metchnikoff was “blackballed” (rejected) by one vote. In protest, Sechenov resigned along with him.

He founded the first bacteriological station in the country at that time in Odessa. But due to an employee mistake (they spoiled the anthrax vaccine) an entire flock of sheep died. After this scandal, he left Russia. The station — on Leo Tolstoy Street.

In Paris, he was immediately taken under the wing of Louis Pasteur (the father of pasteurized milk), who supported his theory and gave him a lab in his institute. There, Metchnikoff worked for 28 years, becoming the deputy director.

While studying cholera at the Pasteur Institute, Metchnikoff proposed a theory that not everyone who comes into contact with the pathogen gets sick. He suggested that it’s all about… (of course) the gut flora. To prove it, he deliberately drank a culture with cholera vibrios. Nothing happened (it would have surely happened to you, Metchnikoff thought)

In the end, he received the Nobel Prize for the discovery of phagocytosis (cellular immunity). He is also “the father of gerontology” — Metchnikoff was the one who proposed the theory that to achieve longevity, one must combat bad bacteria in the gut with probiotics. Now, they say, gerontologists around the world drink sour milk on May 15th remembering Metchnikoff.

He died in Paris, and his ashes are kept in the library of the Pasteur Institute.

Also, in the English Wikipedia he’s Élie Metchnikoff. Not easy to guess.

In the photo, Metchnikoff and Leo Tolstoy are discussing immunology.

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