From Opera to Oblivion: The Fascinating Journey of Lorenzo Da Ponte | September 22 2025, 18:53

We just finished watching Le Nozze di Figaro with Nadezhda in a serialized mode and today we’ll continue with Don Giovanni, also in a serialized mode, because no one has the time. So, both of these operas were written by an American 🙂 I mean the librettos. Turns out, Lorenzo Da Ponte, an Italian librettist, emigrated, naturalized in the U.S., lived here 33 years, taught Italian literature at Columbia University in New York, founded an opera theater in the USA, which became the precursor to the New York Academy of Music and the New York Metropolitan Opera. Really an interesting dude. His real name was Emanuel Conegliano. A Jew by birth, who became a Catholic priest, a friend of Casanova, and a supporter of Rousseau’s ideas. Before moving to the U.S., Da Ponte successfully juggled teaching and a small business, earning not so much from lectures as from owning a brothel for aristocrats which he maintained. In the U.S., he kept a grocery store in New Jersey and tried selling medicines in Pennsylvania. Lorenzo Da Ponte died on August 17, 1838, in humiliating poverty, a few blocks away from the boarded-up building of his theater. His grave in one of the New York cemeteries, which was not marked, eventually got lost. Essentially, the same post-mortem fate befell his friend Mozart.

Echoes of Anthrax: The Amerithrax Investigation Unveiled | September 02 2025, 13:33

From the museum of the day before yesterday. Probably, some of you remember the notorious case in 2001: shortly after the 9/11 attacks, the USA experienced a series of bioterror attacks: someone mailed letters containing powder with anthrax spores (Bacillus anthracis). This led to the deaths of 5 people and infected 17, but it could have ended much worse for the entire planet. The investigation, known as “Amerithrax,” was conducted by the FBI in collaboration with other agencies and became one of the most complex in history.

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For those who might not know — the inhalational form of anthrax has a mortality rate of 85–90% without treatment. Symptoms appear after 6 days, by which time dozens will be infected. It can’t be destroyed — spores remain viable for decades in the soil. For example, on the Scottish island of Gruinard, they lingered for nearly 50 years after wartime testing. Only after 50 years had passed and after 280 tons of formaldehyde solution had been sprayed across all 196 hectares of the island, and the most contaminated topsoil around the dispersal site had been removed, did the island become relatively safe. Thus, anthrax could easily be more terrifying than a global nuclear war.

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So, returning to the subject. Initially, suspicions fell on various individuals, including Iraq or Al-Qaeda, but no evidence was found.

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The key breakthrough was scientific examination. Scientists analyzed the anthrax strain from the letters — it was the Ames strain used in American laboratories. Using microbial forensics (genetic analysis), they identified unique mutations in the spores that narrowed the source down to flask RMR-1029 in the USAMRIID (United States Army Medical Research Institute of Infectious Diseases) laboratory at Fort Detrick, Maryland.

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In other words, every living being has names and genealogy from birth, it’s just a matter of willingness to dig into the genealogy. Apparently, controlled substances have their own registry office, so to speak.

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Bruce Ivins, a microbiologist who worked there, was the custodian of this flask and had direct access (although more than 100 others did as well).

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Later, investigators gathered circumstantial evidence. Ivins had been working late at the lab just before the mailings in September and October 2001, which was inconsistent with his usual schedule. He could not convincingly explain these hours. Moreover, in early September 2001, he was vaccinated against anthrax, which seemed suspicious. The FBI also accused him of attempting to mislead the investigation: he allegedly provided false anthrax samples to divert suspicion and attempted to frame colleagues. In 2001, Ivins sent an email to colleagues offering the Ames strain for analysis, which might have been an attempt to cover his tracks.

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Behavioral signs also played a role. Ivins suffered from depression and suicidal thoughts, especially after another suspect (Steven Hatfill) was cleared in 2008. In June 2008, he was hospitalized in a psychiatric clinic, where during therapy, he made statements that the FBI interpreted as “denials without denial” — for example, that he “had no heart for killing” and did not remember participating in the attacks.

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By 2008, the investigation had narrowed down to Ivins. When he learned that charges were being prepared against him, on July 29, 2008, he took a lethal dose of Tylenol (acetaminophen). Formal charges were never brought. In 2010, the FBI officially closed the case, declaring Ivins the sole perpetrator.

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However, the conclusions remain controversial: the US National Academy of Sciences noted in 2011 that the genetic examination was not convincing enough for a definitive conclusion, and some microbiologists, victims’ families, and politicians demanded further investigation. As of now, no new discoveries have been made, and the case is considered closed.

From Miniare to Miniature: The Evolution of Book Illustration | August 14 2025, 14:52

How interesting, the word “Miniature” turns out not to derive from minimus (Latin), meaning “smallest”, but from miniare, meaning “to color with cinnabar or red lead”.

The word is connected to the practice of book illustration in the Middle Ages. You have probably seen images of medieval manuscripts with dense black text and a large, decorated initial letter. In the earliest bound books, they were not so ornate—just a big letter, colored red to stand out. In Italy, the verb miniare referred to the stage of painting red initials, usually left until last, and the art of illustration itself was called miniatura.

Over time, these initial decorations became increasingly complex, evolving into fully developed scenes with little figures, animals, and buildings. But, of course, since the scenes had to fit into the corner of a page, they were very small. And therefore, because a miniature in a book was like a tiny painting, the meaning of the word expanded—it came to denote any small version of something larger.

Decade Without Police Sirens: A Personal Observation in Public Safety Trends | August 02 2025, 23:48

Interestingly, I haven’t heard a single car siren in almost ten years, except from medical and fire vehicles. At least around here, it seems even the police don’t use them for their purposes. Apparently, the reason is that a police car with a siren behind is perceived as a command to stop and be ready to show your documents. But fire trucks and ambulances, it seems, always use theirs.

Many people don’t know that what we think of as an ambulance doesn’t really exist here. That is, you can call 911 and request a medical vehicle, and they will come, but it’s usually only done in truly critical situations—like a heart issue or if you’ve fallen from a staircase and can’t get up.

This service, EMS, always sends a bill. The minimum is $550, but typically more than $1000, depending on the type of vehicle sent—which depends on what was said on the phone—and how many miles it is to the hospital.

If transportation to a hospital is necessary, an insurance company, Medicare, or Medicaid initially pays for it. The patient might only need to pay the difference—for example, a co-pay or a deductible. If the person is unable to pay due to financial hardship, CNS will not send the bill to collections nor will they recover the debt.

If you call 911 and report that someone has fallen from a ladder, especially with a suspected head, neck, or back injury, the dispatcher will send a full fire & EMS response. That means, besides the medics, this big red fire truck shows up. It arrives not because there’s a fire, but because it is staffed with EMTs (Emergency Medical Technicians) who can begin assistance even before the ambulance arrives. Additionally, fire stations in the area are positioned such that the nearest fire truck can get there faster than a free ambulance.

In various incidents, if you can get to the hospital on your own, experience shows that it’s often necessary to go if you want results. This is not free either. Every such visit costs me $200 (insurance pays ten times more), but as it turned out later, it was always worth it. You just need to know where to go, and choose large facilities where the queues are shorter.

How Frequent Tick Bites May Reduce Lyme Disease Risk | July 01 2025, 04:38

#science Today I found another tick on me; it didn’t have time to latch on, but did manage to bite. And like before, I suffer from these tick bites being very itchy and taking a long time to heal. A couple of times because of similar symptoms I ended up in Emergency, where I was diagnosed with Lyme based on symptoms and put on doxycycline, but later tests did not confirm Lyme, though I already took the doxycycline. And if there was anything, it’s long dead. Question is, why do ticks love me so much.

I just found an interesting scientific article about this. “Hypersensitivity to Ticks

and Lyme Disease Risk” (link in comments)

The authors say that many people living in areas with a high prevalence of tick-borne diseases such as Lyme develop a more acute reaction to tick bites—redness and severe itching, a dermatological-hypersensitivity reaction—that’s exactly my case. They analyzed 1,500 cases and concluded that the more frequent a person’s itching after a bite (more than 3 times a year), the lower their chance of contracting Lyme disease—the risk was reduced by about 7 times (odds ratio ~ 0.14, p=0.01).

They write that this is linked to the fact that the itching helps to notice the tick sooner, consequently – remove it faster and prevent the infectious agent from entering the body (borrelia is not transmitted immediately, but after 1–2 days). There may also be immune mechanisms that interfere with the tick’s feeding and transmission of borrelia.

Conclusion: Recurring reactions to tick bites (itching + redness) create a kind of “anti-tick” immunity. This reduces the risk of contracting Lyme disease, and likely, could be the basis for developing a vaccine against tick pathogens. Quite intriguing, because such medications exist for dogs (full protection against ticks), but haven’t been invented for humans yet.

Risks of High-Pressure Activities on Eye Health and Hearing | June 28 2025, 23:52

Interesting. I learned, for example, that the human retina is not really attached to the vascular tunic, but is held in place only mechanically by intraocular pressure. Because of this, those who jump from heights or engage in diving, and generally anything that increases intraocular pressure, are at risk of retinal detachment.

(By the way, about pressure, I had a slight barotrauma in my left ear today during airplane landing: after landing there was a lingering feeling of stuffiness and muffled sounds, and while in the air it even hurt a bit. That is, some traces of sensation remained several hours later, but probably, by tomorrow morning I will recover fully).

https://youtu.be/QmX60IgWCGk?si=GrWzDtuZTpFeig-X

From Drugs to Souvenirs: The Bizarre Market for Fake Medications | June 22 2025, 17:11

Look how they sell Ozempic, right along with sneakers and souvenirs. In the pharmacy here, they sell antibiotics and opioid pain relievers.